Comprehensive lists of autoantigens, i.e., the body’s own molecules, mainly proteins that become targets of the body’s own antibodies, autoantibodies, are available but they’re not easy to find especially for non-specialists.

Typically, researchers specializing in one autoimmune condition or disease periodically write reviews on the topic and such reviews typically tabulate the most common autoimmune targets identified thus far in that condition or disease.

For example, a 2012 review article lists 81 autoimmune diseases along with their prominent targets (1).

However, recently some researchers have made the effort to trawl through thousands of papers published over several decades and collated the information about autoantigens targeted by autoantibodies scattered across them. The result is an alphabetized and searchable database they call AagAtlas database 1.0 (2). It is freely accessible here: AAgAtlas-index

Its Browse & Download section offers an A-to-Z downloadable list of autoantigens identified thus far. Expectation is this database will be periodically updated.

A more user-friendly database would be one that also allowed disease-specific searches.

The Immune Epitope Database, IEDB.org: Free epitope database and prediction resource, is very comprehensive, constantly updated and does allow disease-specific searches for autoantibody targets. However, using it requires some finagling and patience. For example, searching for autoantibody targets (autoantigens) identified using all types of B cell assays for multiple sclerosis in humans would pull up a total of 243 autoantigens (see below).

Bibliography

1. Hayter, Scott M., and Matthew C. Cook. “Updated assessment of the prevalence, spectrum and case definition of autoimmune disease.” Autoimmunity reviews 11.10 (2012): 754-765.

2. Wang, Dan, et al. “AAgAtlas 1.0: a human autoantigen database.” Nucleic acids research (2016): gkw946. AAgAtlas 1.0: a human autoantigen database | Nucleic Acids Research | Oxford Academic

https://www.quora.com/Where-can-I-find-a-comprehensive-list-of-autoimmune-antibodies-and-their-targets/answer/Tirumalai-Kamala

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