Yes, so far several veterinary but no human DNA vaccines have been approved for use (see below from 1).

Approved Prophylactic Veterinary DNA Vaccines

West Nile Innovator® against West Nile fever – Wikipedia virus in Horses. The US USDA approved this vaccine in 2005. Contains two genes encoding West Nile virus proteins (2).

Apex-IHN® against Infectious hematopoietic necrosis virus – Wikipedia (Rhabdoviridae – Wikipedia) disease in farm-raised Atlantic Salmon. Consists of a plasmid containing a virus glycoprotein gene (3).

Approved Therapeutic Veterinary DNA Vaccine

Oncept™ against Oral Malignant Melanoma in Dogs. This vaccine encodes human tyrosinase. Rationale is it would drive cross-reactive cytotoxic T cell responses against dog tyrosinase highly expressed by melanomas (4). Cross-reactive in this context means once activated by this DNA vaccine, dog T cells specific for peptides derived from human tyrosinase would then respond to similar peptides derived from dog tyrosinase. Keep in mind, this isn’t a stand-alone DNA vaccine effective against a tumor all by itself. It’s only been shown to be effective as an adjunct to surgery for oral malignant melanoma in dogs, i.e., when done after primary tumor’s been surgically removed.

Approved Gene Therapy Veterinary DNA Vaccine

DNA plasmid that expresses the natural form of the Growth hormone–releasing hormone – Wikipedia (GHRH). When given to reproductive age sows, it reduces fetal ill-health and deaths, and thus increases number of surviving babies per litter (5, 6).

Bibliography

1. Pereira, Vanessa Bastos, et al. “DNA vaccines approach: from concepts to applications.” World Journal of Vaccines 4.02 (2014): 50. https://pdfs.semanticscholar.org…

2. Davis, Brent S., et al. “West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays.” Journal of virology 75.9 (2001): 4040-4047. West Nile Virus Recombinant DNA Vaccine Protects Mouse and Horse from Virus Challenge and Expresses In Vitro a Noninfectious Recombinant Antigen That Can Be Used in Enzyme-Linked Immunosorbent Assays

3. Garver, Kyle A., Scott E. LaPatra, and Gael Kurath. “Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon.” Diseases of aquatic organisms 64.1 (2005): 13-22. http://www.int-res.com/articles/…

4. Grosenbaugh, Deborah A., et al. “Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor.” American journal of veterinary research 72.12 (2011): 1631-1638. https://www.researchgate.net/pro…

5. Khan, Amir S., et al. “Effects of maternal plasmid GHRH treatment on offspring growth.” Vaccine 28.8 (2010): 1905-1910.

6. Khan, Amir S., et al. “A comparison of the growth responses following intramuscular GHRH plasmid administration versus daily growth hormone injections in young pigs.” Molecular Therapy 18.2 (2010): 327-333. http://www.cell.com/molecular-th…

https://www.quora.com/Are-DNA-vaccines-used-today/answer/Tirumalai-Kamala

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